Carbon Nanotubes Kill Breast Cancer Stem Cells - Nanotechnology ...

Abstract:
Breast cancer stem cells, the slow-growing, hard-to-kill malignant cells that are thought to be responsible for the growth and spread of breast cancer, have proven remarkably resistant to traditional chemotherapy and radiation therapy. Now, researchers at Wake Forest Baptist Medical Center have shown that multi-walled carbon nanotubes (MWCNTs) injected into breast tumors and irradiated with a quick, 30-second laser beam, are effective at killing breast cancer stem cells.

Bethesda, MD | Posted on April 5th, 2012

Suzy Torti led the research team that conducted this work. She and her colleagues published their finding in the journal Biomaterials. Earlier work by Dr. Torti's research team had demonstrated that MWCNTs irradiated with short laser pulses generate heat that can kill kidney tumors.

Using a mouse model of human breast cancer, the researchers injected tumors containing breast cancer stem cells with MWCNTs, which consist of concentric tubes of graphite. By themselves, nanotubes do not kill tumors, but if they are exposed to laser-generated, near-infrared radiation they start to vibrate and produce heat. This combination can produce a local region in the tumor that is hot enough to kill any tumor cell, not just those that are growing rapidly.

Using this method, the group was able to stop the growth of tumors that were largely composed of breast cancer stem cells. Breast cancer stem cells have high levels of the protein hsp90 which enables them to adapt to higher temperature fluctuations. The investigators showedthat rapid induction of high temperatures by the laser induces cell death by a process known as necrosis even when hsp90 is present. In fact, tumor-bearing mice treated with this therapy experienced complete tumor regression and long-term survival. These findings suggest that nanotube-mediated thermal treatment can eliminate both the differentiated cells that constitute the bulk of the tumor and the cancer stem cells that drive tumor growth and recurrence.

This work, which was supported in part by the National Cancer Institute, is detailed in a paper titled, "The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy." An abstract of this paper is available at the journal's website.

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About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today?s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright ? The National Cancer Institute (NCI)

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LNG Tanker Due at UK South Hook Next Week>> LNG World News

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UK?s South Hook LNG terminal is expected to receive a cargo of LNG on April 14, according to the Milford Haven Port Authority website.

The Rasheeda LNG tanker, with a capacity of?266,oo0 cbm, is sailing from Ras Laffan, Qatar.

The South Hook terminal can process 15.6 million tonnes of LNG a year and is capable of delivering 21 billion cubic metres of gas a year into the UK?s national transmission system.

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Getting Organized After A Cancer Diagnosis - Breast Cancer Answers

Rob Harris shares with us in this video how important it is to get organized after a cancer diagnosis in your family. Divide your life up into important categories to prioritize and list responsibilities in each which will help you take care of the necessities. Other resources like a calendar with doctors appointments and prescriptions, and detailed advance directives help a caregiver and their patient to feel in control.


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Rob Harris is a caregiver to his wife, Cindy, who is a two-time cancer survivor. Presently, she continues to experience challenges with a leg amputation that has forced her to remain wheelchair-enabled. His professional areas of expertise include: strategic business partner, employee relations, stand-up trainer and course developer. In his spare time he writes, blogs and enjoys cooking and sports. He is passionate about reaching out to caregivers and all others to offer support, advice, and encouragement.?Learn more about Rob on his website, http://www.robcares.com.

This information should not be relied upon as a substitute for personal medical advice, diagnosis or treatment. Use the information provided on this site solely at your own risk. ?If you have any concerns about your health, please consult with a physician.

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Flyers Eliminate Sabres From NHL Playoffs In 2-1 Win

Flyers Sabres

PHILADELPHIA, PA - APRIL 05: Matt Read #24 of the Philadelphia Flyers scores the game-winning goal against the Buffalo Sabres on April 5, 2012 at the Wells Fargo Center in Philadelphia, Pennsylvania. The Flyers went on to defeat the Sabres 2-1. (Photo by Len Redkoles/NHLI via Getty Images)

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PHILADELPHIA -- Buffalo center Tyler Ennis sat dejected, staring down at a half-full equipment bag. Slowly, he picked himself up, leaned forward and began to untape.

Asked for his thoughts on the Sabres' elimination from postseason contention, Ennis stared straight ahead, tousled his sweat-soaked hair, and solemnly said: "Not right now."

Not now. Not in the postseason, either.

With their faint playoff hopes riding at least on wins in their final two games, the Sabres failed to finish a longshot rally that brought them to the brink of the postseason.

Matt Read and Marc-Andre Bourdon each scored third period goals to lead the Philadelphia Flyers to a 2-1 win Thursday night over Buffalo that eliminated the Sabres.

"It's disappointing. It's embarrassing to miss the playoffs," Sabres goalie Ryan Miller said. "We have a lot of talented players on this team and we just didn't get it going early enough this season."

The Sabres needed to beat the Flyers to stay alive heading into their final game of the season. The Sabres failed to handle the Flyers, and when the Capitals beat Florida 4-2, Buffalo was done.

Buffalo tried to join the 1994 New York Islanders in becoming the NHL's second team to rally from a 10-point deficit in mid-February to make the playoffs.

Miller stopped 33 shots, yet he was beat by Read on a breakaway with 4:21 left in the game to end Buffalo's bid.

The Sabres were suddenly back in the hunt after completing a frantic comeback by rallying from a pair of two-goal third period deficits in a 6-5 overtime win over Toronto on Tuesday. That pulled Buffalo even with Washington.

The Sabres mounted a remarkable second-half surge in which they went 20-7-5 in last 32 games entering Thursday.

The 33rd game did them in.

"We just didn't finish," Sabres coach Lindy Ruff said. "We had our chances, and we didn't get the kind of shots we needed. There were far too many chances by the wayside."

The Flyers secured the fifth seed in the Eastern Conference after Pittsburgh's 5-2 win over the New York Rangers. The Penguins will play the Philadelphia Flyers in the first round.

"I feel confident about where we went in the month of March and how we played in April," Flyers coach Peter Laviolette said.

The Flyers eliminated the Sabres in Game 7 of the opening-round playoff series last season.

Buffalo grabbed a 1-0 lead in the second when Ville Leino played spoiler against his former team.

Leino, part of Philadelphia's 2010 Eastern Conference championship team, scored his eighth goal with 2:34 left in the second period. He was in the crease to knock a rebound into an empty net after Ilya Bryzgalov strayed to block the previous shot. Bryzgalov had 25 saves.

Leino was fifth on the Flyers last season in scoring with a career-best 53 points (19 goals, 34 assists). The Sabres signed him to a $27-million, six-year deal and he hasn't come close to matching that production.

Bourdon tied the game early in the third with a slapper that spoiled Miller's shutout bid.

Read took the puck at center ice and went all the way to beat Miller for the late winner, crushing playoff dreams in upstate New York.

Washington has 90 points to Buffalo's 88. The Capitals own the tiebreaker because they have more non-shootout wins.

The Sabres were tentative early and took only three shots in the first period.

"We did this to ourselves," Miller said.

It's sure to be a heated postseason series when the Flyers and Penguins open next week in Pittsburgh. Laviolette was fined $10,000 after calling out counterpart Dan Bylsma for sending out his checking line late in Philadelphia's 6-3 win at Pittsburgh on Sunday.

Penguins assistant Tony Granato, who stepped on the top of the side boards and in between the two head coaches, was also fined $2,500.

They face each other Saturday in the regular-season finale.

"It's going to be weird knowing the game doesn't mean anything," Flyers forward Claude Giroux said.

Flyers forward Jaromir Jagr interrupted a Giroux interview scrum in the locker room with a wide smile as he listed to the Q&A.

"You ever play in the playoffs before?" Giroux asked Jagr.

Jagr smiled and yelled, "I never missed the playoffs," as he walked away smiling.

Oh, Jagr's missed the playoffs before. But he has won a pair of Stanley Cups with Pittsburgh and is back in the postseason after spending the last three seasons in Russia. It's his turn now to play spoiler in Pittsburgh ? just like the Flyers did for Buffalo.

Notes: The Flyers presented their year-end awards before the game. Giroux was named team MVP, Kimmo Timonen was outstanding defenseman, Scott Hartnell won most improved player, and Jagr was named the Flyer who best illustrates character, dignity and respect for the sport both on and off the ice. ... The Flyers swept the season series 4-0. ... The Flyers finished 22-13-6 at home.

Contribute to this Story:

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Digital Photography -How to Organise, Edit, Discover (and Not Lose ...

[unable to retrieve full-text content]Don't be afraid to place considerable format framed prints into present shops. There are a lot of buyers out there if your photography is up to conventional. For vacationer retailers, mounted images will operate significantly ...

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Will Illinois ever crack down on unlicensed rental agents?

Chicago renters and landlords have been plagued for years by a rental services industry that operates as if there were no law enforcement in Illinois. Consumers have been howling about rental services? tactics at Yelp and other venues for years, to little effect. It?s a subject we?ve repeatedly covered at YoChicago, and we?ve published a periodically updated rental services do-not-call list.

Unlicensed agents frequently document their transgressions online in the bios on their company websites, and in their LinkedIn and Facebook profiles. They leave enough of a trail that it would be easy for the State to put them out of business ? and perhaps put a few in jail to send a message to the rest. How difficult can it be to cross-match payroll / check records against licensing dates?

Consider, for example, the case of one Anthony Zammitt. His LinkedIn profile (partial screen cap above) describes him as a ?Real estate broker? and both a buyer?s and seller?s agent. He?s not licensed by the State of Illinois as a real estate broker, and he?s legally barred from representing buyers or sellers.

Zammitt?s LinkedIn profile says he started with American Realty Pros in July of last year. He was issued a Leasing Agent license on January 18th of this year ? well beyond the 120-day permit period allowed by law. A licensed Leasing Agent is not legally able to represent buyers or sellers in a real estate transaction, or to hold himself out as doing so.

TIP: The easy way to avoid unlicensed agents, and all of the risks associated with those agents, is to work with a major brokerage firm. Established brokerage firms (a number are advertising clients of ours) don?t tolerate the practices that are common in the rental services industry.

Related posts:

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Benefits of Density Training. A Stealth Method for Results. | Stealth ...

Barbell SquatDensity training?is a fantastic training method for building muscle, shedding fat, and many other benefits.

If you?re stuck in a rut with your training, I?ll explain why Density Training (DT) may be a great solution to kick start your muscle gains and shed body fat at an amazing rate.

DT is simply training by time, not by reps.

DT is defined as volume over time.

Let?s define volume. ?Volume is the amount of work you do in a given session. ?It?s the weight multiplied by the reps (weight x reps).

We?ll keep the math simple to illustrate this point.

For example, if you squat 200 pounds for 5 sets in one session (200 x 5), the volume is 1000 pounds.

Whatever the weight is, multiply that by the reps and you have the volume for that session. ?Easy to figure out right?

Let?s assume those squats took you 20 minutes to complete. ?The density would be 1000 pounds/20 minutes, which equals a density of 50 pounds per minute.

Now, let?s say the next session you did the same volume (1000 pounds), but reduced the training time to 15 minutes, not 20. ?The density for that session would be 66.6 pounds per minute.

You can see that the density of your workout would be increased significantly.

I will note, you can only compare density across the same lifts or combinations. ?You must only compare the same density of squat volume to squat volume, not to shoulder presses or other exercises.

You could also perform DT like this:

20 kettlebell swings, 10 pullups. ?Complete as many rounds as you can in 8 minutes.

Would you think any of these examples are easy? ?Try them and get back to me.

DT is hard. ?It?s very hard and physically demanding.

But, DT allows you to track workout progression with simple math.

And, it offers massive benefits.

Increased density requires increased intensity.

Now, let?s talk about those benefits.

The benefits of DT are many. ?You can probably guess that you?re going to get serious results from this type of training.

1-Hormonal changes. ?Assuming you?re doing compound, multi joint exercises, you?re going to stimulate key hormones such as growth hormone and testosterone.

Remember, these are key for muscle building and fat loss.

These are the powerful hormones we want to stimulate when we train.

Big exercises, such as deadlifts, squats, kettlebell swings, or military presses will stimulate elevations in growth hormone and testosterone.

Since density training increases intensity, this may elevate your hormones to an even greater extent for better results.

2-Mental Toughness. ?Again, DT is hard.

This may be one of the toughest types of training methods you can do.

You may fatigue quite quickly and want to quit.

DT requires mental toughness to continue and you?ll have to dig deep within yourself to push through and complete the time.

*One caution I will mention about DT is this.??Do not sacrifice form or technique.

Do not risk injury and always listen to your body.

Fatigue is one thing, pain and poor form is another. ?Understand the difference.

Train smart. ?I hope I?ve made the point clear, I do not advocate DT if form or technique suffers.

Don?t get ?sloppy.?

3-Body Composition changes. ?Because of the potential hormonal changes this may stimulate, lean muscle mass will increase.

This type of training also has a cardiovascular component to it, as you can imagine.

The element of training for time and not reps, speeds things up.

Obviously, this requires more energy expenditure and will burn more calories, elevating your metabolism.

4-Clear progression. ?As illustrated above, you can track and see progress by improving your density per minute.

You can also improve your completed rounds or reps in the allotted time.

DT offers clear, objective improvement in your training progressions.

It?s fun, challenging, and keeps you motivated to drive for improvement.

Density training is, without question, a stealth method for muscle building and fat loss.

I?ll finish up by explaining how to best use this type of training method.

As with any other type of program, it really depends on your goals.

In general, this is not something you?ll do all the time.

Yes, it offers great benefits, but it?s not to be over done and it?s best to use it as a training cycle (a few weeks) or even as a ?challenge? workout that you add in from time to time.

Remember my caution, NEVER sacrifice form or technique.

I mentioned in the beginning of this article, if you?re stuck in a rut with your training, this method can be a great solution.

Density training is definitely a great way to cycle your training and it?s another type of training method you can use to jump start your progressions and break through plateaus.

Questions or comments, post them below.

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