French businesses fear "systematic strangling"

[ [ [['Connery is an experienced stuntman', 2]], 'http://yhoo.it/KeQd0p', '[Slideshow: See photos taken on the way down]', ' ', '630', ' ', ' ', ], [ [['Connery is an experienced stuntman', 7]], ' http://yhoo.it/KpUoHO', '[Slideshow: Death-defying daredevils]', ' ', '630', ' ', ' ', ], [ [['know that we have confidence in', 3]], 'http://yhoo.it/LqYjAX ', '[Related: The Secret Service guide to Cartagena]', ' ', '630', ' ', ' ', ], [ [['We picked up this other dog and', 5]], 'http://yhoo.it/JUSxvi', '[Related: 8 common dog fears, how to calm them]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 5]], 'http://bit.ly/JnoJYN', '[Related: Did WH share raid details with filmmakers?]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 3]], 'http://bit.ly/KoKiqJ', '[Factbox: AQAP, al-Qaeda in Yemen]', ' ', '630', ' ', ' ', ], [ [['have my contacts on or glasses', 3]], 'http://abcn.ws/KTE5AZ', '[Related: Should the murder charge be dropped?]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 5]], 'http://yhoo.it/JD7nlD', '[Related: Bristol Palin reality show debuts June 19]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 1]], 'http://bit.ly/JRPFRO', '[Related: McCain adviser who vetted Palin weighs in on VP race]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['Titanic', 7]], 'http://news.yahoo.com/titanic-anniversary/', ' ', 'http://l.yimg.com/a/p/us/news/editorial/b/4e/b4e5ad9f00b5dfeeec2226d53e173569.jpeg', '550', ' ', ' ', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

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Immune system 'circuitry' that kills malaria in mosquitoes identified

Friday, June 8, 2012

Researchers at the Johns Hopkins Malaria Research Institute have, for the first time, determined the function of a series proteins within the mosquito that transduce a signal that enables the mosquito to fight off infection from the parasite that causes malaria in humans. Together, these proteins are known as immune deficiency (Imd) pathway signal transducing factors, are analogous to an electrical circuit. As each factor is switched on or off it triggers or inhibits the next, finally leading to the launch of an immune response against the malaria parasite. The study was published June 7 in the journal PLoS Pathogens.

The latest study builds upon earlier work of the research team, in which they found that silencing one gene of this circuit, Caspar, activated Rel2, an Imd pathway transcription factor of the Anopheles gambiae mosquito. The activation of Rel2 turns on the effectors TEP1, APL1 and FBN9 that kill malaria-causing parasites in the mosquito's gut. More significantly, this study discovered the Imd pathway signal transducing factors and effectors that will mediate a successful reduction of parasite infection at their early ookinete stage, as well as in the later oocyst stage when the levels of infection were similar to those found in nature.

"Identifying and understanding how all of the players work is crucial for manipulating the Imd pathway as an invention to control malaria. We now know which genes can be manipulated through genetic engineering to create a malaria resistant mosquito" said George Dimopoulos PhD, professor in the Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health.

To conduct the study, Dimopoulos's team used a RNA interference method to "knock down" the genes of the Imd pathway. As the components were inactivated, the researchers could observe how the mosquito's resistance to parasite infection would change.

"Imagine a string of Christmas lights or other circuit that will not work when parts aren't aligned in the right sequence. That is how we are working with the mosquito's immune system," explained Dimopolous. "We manipulate the molecular components of the mosquito's immune system to identify the parts necessary to kill the malaria parasites."

Malaria kills more than 800,000 people worldwide each year. Many are children.

###

Johns Hopkins University Bloomberg School of Public Health: http://www.jhsph.edu

Thanks to Johns Hopkins University Bloomberg School of Public Health for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Wii U unlocks the key to the Miiverse, Nintendo promises mobile integration to come

As its pronoun heavy name indicates, the Wii U is all about the social. With that in mind, Nintendo president Satoru Iwata unveiled the Miiverse, a coming together of players' avatars that will live on the console's home screen. Log in, and you'll see your Mii, your friends' Miis, Miis on your Wii U system and Miis of folks playing the same game as you in your locality. The Mii Wara Wara features Miis gathered around tiles representing Wii U games, with speech bubbles offering up real messages from other players.

There's plenty of social functionality built into the touchscreen controller, as well, users can text with other players to get information -- like gaming tips. Info can be input with a virtual keyboard, smartphone-style or can be handwritten or doodled with a stylus, à la the 3DS. The controller also seems to be a useful tool when using your system to teleconference on the big screen, so you can, say browse the web for info while chatting, tablet-style.

Nintendo has also promised more integration with with non-Wii devices -- functionality that likely won't hit at launch. Since the information is accessible via mobile browser, you'll be able to carry social functionality over to your 3DS, PC and mobile phone -- it's not Super Mario for iOS, but it's a small step toward a more mobile Nintendo, we guess.

Update: Join us past the break to view the webstream for yourself!

Continue reading Wii U unlocks the key to the Miiverse, Nintendo promises mobile integration to come

Wii U unlocks the key to the Miiverse, Nintendo promises mobile integration to come originally appeared on Engadget on Sun, 03 Jun 2012 19:02:00 EDT. Please see our terms for use of feeds.

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George Zimmerman reports back to jail

George Zimmerman, charged in the murder of teenager Trayvon Martin, returned to jail Sunday two days after a judge revoked his bail. NBC's Charles Hadlock reports.

By Charles Hadlock, NBC News, and M. Alex Johnson, msnbc.com

Updated 4 p.m. ET: George Zimmerman, the man charged with second-degree murder in the shooting death of Florida teenager Trayvon Martin, was booked into jail Sunday, two days after a judge revoked his bail after evidence surfaced that Zimmerman and his wife may have misled the court about their finances.


Charles Hadlock is a correspondent for NBC News. M. Alex Johnson is a reporter for msnbc.com. Follow M. Alex Johnson on Twitter and Facebook.


Zimmerman, 28, arrived in the state Saturday night from an undisclosed "secure location," where he has been staying because of "significant threats against his life," his lawyer, Mark O'Mara, said Sunday. He arrived at the jail before 2 p.m. on Sunday.

Zimmerman met police at a business park and was driven to the jail. He was handcuffed and wore a blue checkered button-up shirt. He is being held without bail and is listed as having $500 in his jail account, according to the jail website.?

Zimmerman, a neighborhood watch captain in Sanford, Fla., was released after posting $15,000 in cash on April 20 after he was charged with killing Martin, 17, who was unarmed, in February. The case triggered a nationwide debate about whether race was involved in the shooting; Martin was black, while Zimmerman is the son of a white man and a Peruvian woman.


Zimmerman was quiet and his return to jail went smoothly, Seminole County Sheriff Donald Eslinger said at a news conference Sunday. He said Zimmerman will stay in a single cell as he did before he was released in late April. The cell is 67-square-feet and is equipped with a toilet, two beds, a mattress, pillow, blanket and sheets, according to The Associated Press.

Seminole County Sheriff Donald Eslinger and George Zimmerman's lawyer Mark O'Mara, spoke at a news conference after the former neighborhood watch volunteer surrendered to police.

Key events in the Travyon Martin case

Seminole County Circuit Judge Kenneth Lester revoked Zimmerman's bond Friday after learning that Zimmerman and his wife, Shellie Zimmerman, may have misled him about their assets when he set bond. Prosecutors demonstrated that Zimmerman had at least $135,000 that he did not disclose in a special PayPal account he had set up to pay for his defense.

Zimmerman and his wife testified at a bond hearing that they had little money. During the hearing, Zimmerman also apologized to Martin's parents. The judge set bail at $150,000 -- days later, Zimmerman was released after putting forth 10 percent of the total bail amount.??

But prosecutors listened to recorded jailhouse phone calls and said the Zimmermans talked about the money "in code to hide what they were doing."

Judge revokes bail for George Zimmerman

By concealing the defense contributions, Zimmerman benefited from a lower bond than he might have been granted had he and his family told the truth about how much money they really had, Lester said.

O'Mara said in a posting on the defense team's website that he would seek a new bond hearing, at which he would argue that "the vast majority" of the donated money was in an independently managed trust and that neither "Mr. Zimmerman or his attorneys have direct access to the money."

Wearing a casual, striped button-up shirt Sunday, O?Mara said that Zimmerman is concerned about his and his wife?s safety because of the ?enormous anger and frustration and hatred that has spurred from this case.?

George Zimmerman was expected to be back in jail later Sunday afternoon. NBC's Charles Hadlock reports from Sanford, Fla.

Full coverage of the Trayvon Martin case

Benjamin Crump, an attorney for Martin's family, said Judge Lester's finding that Zimmerman was dishonest is "very important because his credibility is the most important thing in this entire case." Legal experts also told The Associated Press that the judge's questioning on Friday could undermine Zimmerman's credibility in trial. ?

On the defense team's website, O'Mara wrote: "The defense team hopes that Mr. Zimmerman's voluntary surrender to Sanford police will help demonstrate to the court that he is not a flight risk."

But at Sunday's news conference, O'Mara added: ?As Mr. Crump said, there?s a credibility issue that needs to be rehabilitated by explaining away why they did what they did, if that?s what happened.?

Msnbc.com's Isolde Raftery contributed to this report.

More content from msnbc.com and NBC News:

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Ween May Be Gone, But Their 'Good Run' Lives On

With the band (apparently) calling it quits after 25 years, Bigger Than the Sound offers a eulogy.
By James Montgomery


Dean Ween
Photo: Chris McKay/ WireImage

In my review of Ween's 2007 album La Cucaracha (which also happens to be the last time they were mentioned on this website), I referred to them as "musical cockroaches," the kind of scurrying, scrounging band that — much like the titular (and totally gross) arthropod on the record's cover — was capable of surviving nuclear holocausts and subsisting on a bar of soap for weeks at a time.

"In essence, Ween are indestructible," I wrote. "They will be here long after you and I are gone."

It turns out, I was wrong about that last point. Because on Tuesday, Aaron Freeman, better known to bong-rippers and Scotchgard-huffers everywhere as Gene Ween, told Rolling Stone that he was retiring the mantle and ending Ween, saying, simply, "It's been a long time; 25 years. It was a good run."

Of course, this apparently came as a surprise to Freeman's partner for the past quarter-century, Mickey "Dean Ween" Melchiondo, who reportedly wrote on his private Facebook page that the band's breakup "is news to me, all I can say for now I guess." There's been no official announcement on Ween's site, and as late as 2010, the duo were talking about entering the studio to begin work on the follow-up to Cucaracha, though, from the sound of things, those sessions probably didn't go all that well ... if they ever happened at all.

But if this really is the end of the band, well, most fans probably saw it coming. After an infamous onstage meltdown at a Ween show last year, Freeman entered rehab (and just released a solo album, Marvelous Clouds), and in recent years, Melchiondo has devoted most of his time to his side-job as a fishing guide (he describes himself as both a "pretty good conversationalist" and "fully insured"). Still, none of that makes the news any less of a bummer, especially for folks like me, who grew up with Ween, got sh--faced at their live shows — a genuine rite of passage for any fan — spent endless smoky nights dissecting their wildly divergent back catalog and, as a result, would go on to process popular music through their own uniquely cracked spectrum. Freeman is right: It was a good run.

And that's why it's taken me almost a day to write this column. After all, how does one encapsulate their 25-year career, which began in eighth-grade typing class and has encompassed tape-machine schlock, bizarre, brain-addled semi-hits — 1993's "Push Th' Little Daisies" — critical acclaim and Pizza Hut commercials (and master classes in old-school country & western, nautical prog, Beatles-y psych, Buffett-y calypso and, uh, Philly Soul, to name just a few of the dozens of genres they've skewered)? Because of all that, they most certainly rank up there as one of weirdest acts of all time, earning their rightful place alongside the likes of Zappa, Spike Jones, Screamin' Jay Hawkins and Captain Beefheart ... though, to me, Ween were always something more: They were an entry point to all that oddity, the first of their kind. The moment I heard "Dr. Rock" or "The Stallion, Pt. 1" (from 1991's The Pod), I could practically feel my musical consciousness being expanded, and from that moment on, everything was different. In a lot of ways, Ween made me.

I followed them through every twist and turn, often as puzzled as I was delighted (12 Golden Country Greats and The Mollusk remain two of my favorite albums ever). But through it all, Ween remained an important band for me, an old favorite, a reminder of the good times when I didn't know better and when it was socially acceptable to wear basketball shorts and sit cross-legged in smoky dorm rooms all day long. And while nothing I write can effectively eulogize them, I do think that, in closing, it's important to defend them in one regard: No matter what anyone tells you, Ween were never a "joke" band. They were a terrific band, one adept at doing anything — mostly because they wanted to — and brilliant enough to carry it out to the nth degree.

The attention to detail on albums like White Pepper or Mollusk was the kind of thing only true musicians (and music aficionados) could muster — if Ween were gonna do a prog record, you'd better believe it was gonna sound like a prog record — and that held true to the very end. On what might very well end up being their final album track (the smooth-jazz-slaying "Your Party," from La Cucaracha), not only did they nail the buttocks-clenching uprightness of the genre, but they went out and got none other than David Sanborn to play satin-sheet sax on the thing. That goes beyond mere humor; it's pure genius.

And that's what Ween were, to me, and to a whole lot of other people too: musical geniuses. They just managed to hide it for 25 years — though those of us who worship at the altar of the Boognish knew otherwise. Ween may not have lasted forever, but the memories they've soundtracked certainly will. It's a Brown day, indeed.

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UK property owners facing flood insurance problems | Isis Insurance

Isis Insurance, a ?let leading property insurance broker have noted recent comments regarding flood insurance in the UK.

The end of the UK government?s flood insurance agreement could leave property worth over ?200 billion uninsured, it is claimed.

The government?s statement of principles on insuring properties at risk of flooding will end on 30 June 2013 and one in four UK properties is at risk of flooding, meaning up to ?214 billion n of property could be uninsured, according to research by property search firm SearchFlow.

It says that property owners could find themselves unable to insure their properties from the summer of 2012 as insurers become unwilling to offer policies which expire after the principles agreement.

It is warning that uninsured properties could leave owners in breach of their mortgage contract as well as making properties harder to sell or remortgage and reducing their overall value.

According to Know Your Flood Risk UK, many UK insurers are already trying to rid themselves of properties at significant risk of flooding and some property owners have been unable to secure policies with excesses below ?20,000.

?The end of the principles agreement between the Association of British Insurers and the government could make flooding a hugely contentious issue during the conveyancing process when professional conveyancers have to consider the potential risks a property faces,? said Richard Hinton, business development director at SearchFlow.

?Although buyers will be able to obtain flood insurance for the next few months, the long term prospects of properties at risk of flooding are potentially bleak especially for buyers purchasing in high risk flood areas. The possibility of very high premiums, significant reductions in value, less access to mortgage finance, even action taken by the mortgage lender due to breach of the mortgage agreement, is high,? he explained.

?Conveyancers looking after their clients? best interests must ensure they are aware of the risk of flooding and ensure their clients appreciate the danger posed by the end of the ABI agreement,? he added.

The ABI estimates that the floods of 2007 cost more than ?3 billion and that the average bill for the repair of a flooded property is over ?30,000. The Environment Agency currently spends ?300 million per year on flood defences, but nonetheless reports that 43% of defences are in fair, poor or very poor condition.

?The government?s current spending on flood mitigation may seem substantial, but the truth is that much more is needed to address the seriousness of flood risk. Only a tenth of the total cost of the floods of 2007 is spent on flood defences each year. The potential costs of flood damage dwarf the annual spend on defences and this is the main reason why insurers are currently reluctant to expose themselves to flood risk,? said Hinton.

?One of the main principles in the ABI?s agreement was that the government improve flood defences in high risk areas. The fact this has not been done means an extension to the agreement is unlikely,? he explained.

?This is worrying news for those buying in areas with high flood risk. Given that one in four properties in the UK faces a significant risk of flooding, conveyancers everywhere must take notice of the potentially huge dangers a future dearth of flooding insurance may pose,? he added.

Isis insurance has been arranging let property cover for many years and has access to many schemes from some of the UK?s leading ?let property insurance companies with a range of landlords insurance covers available.

Tags: buy to let insurance, isis insurance, let property insurance, property insurance

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Symptoms of Colorectal Cancer | Baby And Women Tips

?Colorectal cancer if detected and treated early can be prevented and treated. Data indicate if this is done then the number of casualties caused by colorectal cancer can be decreased to 50%. This makes an increase in public awareness of colorectal cancer is important to note.
Over the past few years, Colorectal Cancer Awareness Month which falls in March has been celebrated in various countries around the world. Months of colorectal cancer care in Europe was launched at the initiative of colorectal Europacolon patient support groups. Since 2009, Indonesia began to follow the warnings of colorectal cancer regardless of the month so hopefully more people began to recognize the illness and be alert to the symptoms.
Symptoms of colorectal cancer depends on tumor location in the intestine and whether it has spread to elsewhere in the body (metastasis). Most of the symptoms of other illnesses can appear as well, and then there is no mention here are the symptoms of colorectal cancer diagnostics. Symptoms and signs are divided into local, the Constitution (affecting the entire body) and metastatic (caused by spread to other organs).Local
Local symptoms are more likely if the tumor is located near the anus. Maybe there is a change in bowel habits (new onset constipation or diarrhea in the absence of other causes), and the feeling of incomplete defecation (tenesmus) and reduction in diameter of stool; tenesmus and change in stool form is the second characteristic of rectal cancer. Lower gastrointestinal bleeding, including parts of bright red blood in the stool, may indicate colorectal cancer, such as perhaps an increase in mucus. Melena, black stool with a lingering look, usually occurs in the upper gastrointestinal tract bleeding (such as from a duodenal ulcer), but is sometimes found in colorectal cancer when the disease is located at the beginning of the colon.
Tumors that are large enough to fill the entire lumen of the bowel can cause bowel obstruction. This situation is characterized by constipation, abdominal pain, abdominal distension and vomiting. This sometimes leads to obstructed and distended bowel sculpt and cause of peritonitis.
Local specific effects of colorectal cancer occurs when the disease has become more advanced. Large tumors are more likely to see feel the abdomen, and can be seen by a physician on physical examination. Disease can affect other organs, and can cause blood or air in the urine (the invasion of the bladder) or vagina (female reproductive tract invasion).Constitution
If the tumor has caused chronic occult bleeding, iron deficiency anemia can occur: it may be experienced as fatigue, palpitations and see the demeanor (pale appearance of the skin). Colorectal cancer can also cause weight loss, usually due to decreased appetite.
Constitutational symptoms of the more unusual is the Unexplained fever and one of several paraneoplastic syndromes. The most common paraneoplastic syndrome is thrombosis, usually deep vein thrombosis.Metastasis
Colorectal cancer most often spreads to the liver

?This can go unnoticed, but the deposits in the liver
?can cause jaundice and abdominal pain?
(due to stretching of the capsule). If the tumor
?deposit blocking the bile duct, jaundice may be
?accompanied by other features of biliary obstruction,
?such as pale feces.

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John Browett comunica ai dipendenti degli Apple Store che l?aumento di salario avverr? con 3 mesi di anticipo

John Browett, il nuovo vice presidente del settore vendite, ha in questi giorni inviato una lettera ai dipendenti degli Apple Store in cui sostiene che il nuovo aumento di salario programmato per il 30 settembre avverr? con 3 mesi di anticipo, pi? precisamente il 30 giugno.

John Browett ? stato recentemente ingaggiato come il nuovo Vice Presidente del settore vendite di Apple, dopo aver promesso sconti sugli acquisti di Mac e iPad ed aver inviato una lettera di presentazione ai dipendenti degli Apple Store, egli ha diffuso un video in cui spiega che il tanto richiesto aumento di salario avverr? con 3 mesi di anticipo.

In passato infatti si era parlato del possibile incremento della retribuzione programmato per il 30 settembre di quest?anno, in una mossa quasi a sorpresa Browett ha invece affermato che questi avverr? il 30 giugno. Secondo quanto riportato, l?aumento avverr? in scala 1-5. In altre parole, come nella maggior parte dei lavori nel settore delle vendite, l?impiegato ricever? un salario base ed un aumento in relazione a quanti prodotti ? riuscito a vendere; grazie a tale incremento quindi il dipendente potr? ricevere dall?1 al 5% di salario.

[via]

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Crowds gather for Golden Gate Bridge celebration

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