Watson seeks approval of generic version of cancer drug Velcade

In a study conducted by the blog TorrentFreak, HBO's gritty documentary series Game of Thrones was found to be the most illegally downloaded TV show of the year, with six bad apples watching the show without paying for it. Haha, just kidding. In truth, there 4.28 million downloads of one episode this year, meaning many millions more likely accessed the rest of the season. So that is a popular show to pirate! Showtime's screwball comedy Dexter was next on the list, its top episode being stolen 3.85 million times. ...

Source: http://news.yahoo.com/watson-seeks-approval-generic-version-cancer-drug-velcade-154734617--finance.html

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Use Military Retirement Calculator To Anticipate ... - Home and Family

During the first few years of service, retirement income may not be high on everybody's list of concerns. Nonetheless as their career in the army advances, figuring out retirement income with an army retirement calculator can help someone plan for the future. Retirement income for retired army is similar to civilian calculations, and they should include the same variables.

When you?re having a look at your pension plan, begin with your age, and the age at which you plan to retire. In the military, you can consider the quantity of years of service and know what % of your pay you'll receive upon retirement after an established period of years. Using these numbers in a military retirement calculator you can figure if you are going to have to find another job, or can stay home and unwind. Most calculators do not include the final year you?re employed when computing income. For example, if you intend to retire at age 65, the last year of earnings you must consider is for year 64.

When you consider income, don't forget to take into consideration your spouse?s revenue in the household totals and any amounts your married spouse has in their own retirement savings account. Individual retirement accounts should also be included in the military retirement calculator when working out the present pension savings amount.

Future Earnings Estimates Are Questionable

The earnings you realize from your current investments are questionable, at best and depending on where your savings are being held will play a significant role in its growth. A military retirement calculator can work with known numbers, but the variables in interest rates and potential for losses in market investments can make your savings plan unstable. While high-interest accounts are typically safe and consistent, their returns are also a lot lower that investments. Securities dealing however, can be rewarding, financially, they can also take a big slice of your original investment in a down market.

For post-retirement expenses, it is often worked out that 90 percent of your last year?s income will be what you may spend on living costs. When using your military retirement calculator by understanding what your total savings should be upon retirement, and working out how many years you can live on the balance, should help you determine how much more you need to save in order to survive. Knowing the amount of money you need to save can help you calculate the amount each month you've got to put away, figuring in your expected rate of growth.

This work is thanks to advisor hub. Before taking any early pension lump sum or considering a pension release, it could be prudent to order a meeting with a professional consultant as this will impact on your allowance in retirement.


Tags: pension lump sum, Pension plan, pension release

Source: http://homeandfamily.emilie.org/uncategorized/use-military-retirement-calculator-to-anticipate-savings/

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Myanmar to allow daily private newspapers

YANGON, Myanmar (AP) ? Myanmar said Friday it will allow private daily newspapers starting in April for the first time since 1964, in the latest step toward allowing freedom of expression in the long-repressed nation.

The Information Ministry announced on its website that any Myanmar national wishing to publish a daily newspaper will be able to submit an application in February. New papers will be allowed to begin printing April 1 in any language.

The move was an expected part of new press freedoms President Thein Sein has introduced as part of wider democratic reforms since taking office last year, after a half-century of military rule.

In August, the government abolished direct censorship of the media and informed journalists they would no longer have to submit their work to state censors before publication as they had for almost half a century.

Myanmar has state-run dailies which serve as government mouthpieces and more than 180 weeklies, about half of which cover news while the rest feature sports, entertainment, health and other subjects.

Private dailies in Burmese, English, Indian and Chinese languages were once vibrant in the former British colony, previously called Burma. But all were forced to close when late dictator Ne Win nationalized private businesses in 1964.

Under Ne Win's one-party Socialist government the standard of newspapers diminished to propaganda sheets. The most recent military regime ruled by Gen. Than Shwe used the country's three state-owned dailies as junta mouthpieces, which continue to be unpopular with low circulation.

Until just two years ago, this Southeast Asian nation's reporters were regarded as among the most restricted in the world, subject to routine state surveillance, phone taps and intense censorship. The censorship board would shut down newspapers temporarily for violations. Journalists were tortured, imprisoned and subjected to constant surveillance.

Testing their new freedoms, journalists and private publications have become bolder. They have printed once forbidden items including pictures and stories about anti-government demonstrations and sectarian violence. The once highly taboo images of opposition leader Aung San Suu Kyi are now often displayed, even in state-controlled media.

Source: http://news.yahoo.com/myanmar-allow-daily-private-newspapers-083311307.html

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Tell bosses: Careless comments cause lawsuits ? Business ...

We?ve said it before and we?ll say it again: The only appropriate response to a pregnancy announcement is ?Congratulations.? No smart aleck comments, no questions about family size, no wondering aloud how long the employee expects to be out. If the pregnant employee asks about leave, her boss should refer her to HR.

Recent case: Erica was a luxury goods buyer for Gucci America, a subsidiary of the famed Italian company. Her job involved marketing women?s handbags and other leather accessories in the United States. She traveled to Florence several times a year to select goods for the U.S. market. She got excellent reviews and met all her sales goals.

Then the company appointed a new president, who felt the entire company should be revamped. He hired a new general merchandise manager who met with Erica to ?discuss plans to reorganize.

Around the same time, Erica announced she was pregnant. The new general manager, an Italian, bombarded Erica and another pregnant employee with questions about U.S. policies on maternity leave and whether the two expected to take long work breaks after giving birth. She added, ?Wow, all these pregnant girls, what are we going to do with all of them.?

Shortly after, Erica was terminated in a reduction in force and the other pregnant employee was demoted.

Erica sued, alleging pregnancy discrimination. She showed the court that although her job was technically eliminated, a new position with almost identical duties was created and filled by a nonpregnant employee with much less experience.

The company argued its RIF was legitimate, but the court said a jury should decide whether it was merely an excuse to get rid of a pregnant employee. (Crisses v. Gucci America, No. 10-Civ-8393, SD NY, 2012)

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Source: http://www.businessmanagementdaily.com/33480/tell-bosses-careless-comments-cause-lawsuits

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Say Cheese! Mars Rover Curiosity Snaps Amazing Self-Portrait

NASA has snapped its most amazing self-portrait yet of the Curiosity rover on Mars, showing the robot posing with its ultimate destination: a huge Martian mountain.

The new view of Curiosity on Mars is actually a mosaic of dozens of high-definition color photos taken by the rover between Oct. 31 and Nov. 1. The image shows Curiosity surrounded by the tracks of its wheels, with the 3-mile-high (5 kilometers) Mount Sharp rising into the sky in the distance.

NASA featured the latest Curiosity portrait as its image of the day Thursday (Dec. 27) after releasing the photo earlier this month.

The prominent Mount Sharp is the central peak of Curiosity's vast Gale Crater landing site. Another mountain in the image, on the rover's left, makes up the northern wall of the expansive crater.

To create the eye-popping Mars photo, Curiosity used its Mars Hand Lens Imager (MAHLI), a powerful camera mounted at the end of the rover's robotic arm. Curiosity turned the camera on itself much like a human tourist might when traveling alone, snapping a series of photos that rover team members then stitched together into a high-definition composite view.

The rover had to move its robotic arm through more than 50 positions in a single day to capture its entire car-size body on camera. ?NASA scientists used a test version of Curiosity on Earth to practice the Martian photo session.

NASA unveiled an earlier version of Curiosity portrait, composed out of 55 separate images, in early November, but the latest view includes significantly more detail and a wider view.

The Mars rover Curiosity is headed toward a spot near the base of Mount Sharp called Glenelg, and will continue to perform experiments along the way. The $2.5 billion rover's primary mission is to determine if its Gale crater landing site could have ever supported primitive microbial life.

Follow SPACE.com on Twitter?@Spacedotcom. We're also on?Facebook?&?Google+.

Copyright 2012 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/cheese-mars-rover-curiosity-snaps-amazing-self-portrait-172022583.html

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The factor that could influence future breast cancer treatment

Australian scientists have shown in the laboratory how a 'transcription factor' causes breast cancer cells to develop an aggressive subtype that lacks sensitivity to estrogen and does not respond to known anti-estrogen therapies. The research, which has significant implications for breast cancer treatment, is published December 27 in the open access journal PLOS Biology.

Transcription factors are molecules that switch genes on or off. In this case, the transcription factor known as 'ELF5' inhibits sensitivity to estrogen very early in the life of a breast cancer cell. In 2008, Professor Chris Ormandy from the Garvan Institute of Medical Research in Sydney, Australia, showed that ELF5 was responsible for the development of breast progenitor cells into the estrogen-receptor-negative cells that produce milk in the breast during pregnancy.

In the current study, a team led by Ormandy in collaboration with Drs Maria Kalyga and David Gallego-Ortega, has shown that the same molecular decision occurs in breast cancer and that ELF5 has the ability to change an existing tumour into an estrogen-insensitive tumour.

"This work tells us that cancers which become refractory to anti-estrogen treatment often do so by elevating their levels of ELF5 and becoming functionally estrogen receptor negative," said Ormandy.

The team has also described the genetic mechanisms by which ELF5 opposes the action of estrogen, and has shown that it is possible to alter the subtype of breast cancer by manipulating ELF5 levels in cancer cells in the laboratory.

"This raises the therapeutic option of manipulating ELF5 levels to treat breast cancer. As ELF5 is intracellular, this could possibly be done with small molecule therapies that penetrate cells and target protein-to-protein interactions, or with small inhibitory RNAs. There is also the possibility of testing ELF5 levels in tumours to predict response to treatment and therefore guide treatment decisions."

"Our key discovery here is that by simply manipulating one transcription factor we can change the subtype of breast cancer."

More information: Kalyuga M, Gallego-Ortega D, Lee HJ, Roden DL, Cowley MJ, et al. (2012) ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer. PLoS Biol 10(12): e1001461. doi:10.1371/journal.pbio.1001461

Journal reference: PLoS Biology

Provided by Public Library of Science

-->

Source: http://medicalxpress.com/news/2012-12-factor-future-breast-cancer-treatment.html

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White House urges dockworkers, shippers deal

WASHINGTON (AP) ? The White House is urging dockworkers and shipping companies to reach agreement "as quickly as possible" on a contract extension for East Coast and Gulf Coast dockworkers whose existing pact expires this week.

Obama spokesman Matt Lehrich says the White House is monitoring the situation closely and urges the parties to "continue their work at the negotiating table to get a deal done as quickly as possible."

Talks between the dockworkers and shipping companies broke down Dec. 18 amid unresolved issues such as wages and container royalties ? the payments to union workers based on cargo weight. The International Longshoremen's Association and the U.S. Maritime Alliance are expected to meet this week.

The National Retail Federation has asked the Obama administration to use "all means necessary" to prevent a strike.

Source: http://news.yahoo.com/white-house-urges-dockworkers-shippers-deal-172630998--politics.html

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Starvation Didn't Wipe Out Sabertooth Cats

Saber-toothed cats apparently did not go extinct for lack of prey, contradicting a popular explanation for why they died off, fossil evidence now suggests.

Even near their extinction, saber-toothed cats likely had enough to eat, researchers noted.

Saber-toothed cats, American lions, woolly mammoths and other giant creatures once roamed across the American landscape. However, at the end of the late Pleistocene about 12,000 years ago, these "megafauna" went extinct, a die-off called the Quaternary extinction.

"The popular theory for the megafaunal extinction is that either the changing climate at the end of the last ice age or human activity, or some combination of the two, killed off most of the large mammals," said researcher Larisa DeSantis, a vertebrate paleontologist at Vanderbilt University in Nashville. "In the case of the great cats, we expect that it would have been increasingly difficult for them to find prey, especially if had to compete with humans. We know that when food becomes scarce, carnivores like the great cats tend to consume more of the carcasses they kill. If they spent more time chomping on bones, it should cause detectable changes in the wear patterns on their teeth."

Tale of the teeth

To learn more about saber-toothed diets, the researchers analyzed the fossil teeth of 15 saber-toothed cats (Smilodon fatalis) and 15 American lions (Panthera atrox) recovered from the La Brea tar pits in Los Angeles. These specimens ranged from about 11,500 to 35,000 years in age.

To study the fossils, the scientists used dental microwear texture analysis, developed by anthropologist Peter Ungar at the University of Arkansas. This involves using generating three-dimensional images of a tooth's surface. The image is then analyzed for microscopic grooves ? devouring red meat produces small parallel scratches, while biting on bones lead to larger, deeper pits.

The investigation found the pattern of wear on the teeth of the saber-toothed cat most closely resembled those of present-day African lions, which sometimes crush bone when they eat. The wear pattern on American lion teeth, on the other hand, echoed that of the present-day cheetah, which deliberately avoids bones when it feeds. [Photos: A Lion's Life]

Analysis of both older fossils and more recent ones did not reveal any evidence that patterns of wear changed over time, and none had extreme microwear like living hyenas, which consume entire carcasses, bones included. This suggests that prey for these carnivores was not scarce ? the animals were not gnawing their victims to the bone.

"Tooth wear patterns suggest that these cats were not desperately consuming entire carcasses, as was expected, and instead seemed to be living the 'good life' during the late Pleistocene, at least up until the very end," DeSantis said.

Big predator extinction

Past research of teeth from American lions, saber-tooth cats, dire wolves and coyotes from La Brea revealed they experienced three times the number of broken teeth of contemporary predators, hinting that these species were having trouble finding prey and were thus urgently devouring or "processing" whole carcasses. This led scientists to suspect that climate change and human competition were making life tough for the big predators.

Instead, DeSantis and her colleagues argue this high rate of damage seen in teeth more likely resulted during capture of prey instead of feeding on carcasses.

"We expected extinct carnivores to show evidence for extreme bone processing, based on the high number of broken teeth determined from prior research. Finding the complete opposite pattern was shocking!" DeSantis said.

The researchers noted that saber-toothed cats were about the size of today's African lion, while the American lion was about 25 percent larger. They fed on giants such as mammoths and four-ton giant ground sloths. The fact these ancient carnivores and their prey were bigger than contemporary predators and their victims could help explain why the extinct cats had more broken teeth than their living brethren, the investigators said. . [Gallery: Today's Threatened Mammals]

Specifically, larger teeth break more easily than smaller teeth, so larger carnivores may be likely to break more teeth when attempting to take down larger prey. The researchers noted past studies that found the canines of a predator the size of fox can support more than seven times the fox's weight before breaking, while a carnivore the size of lion can only support about four times its weight and the curved teeth of saber-toothed cats could only support about twice the animal's weight.

"The net result of our study is to raise questions about the reigning hypothesis that 'tough times' during the late Pleistocene contributed to the gradual extinction of large carnivores," DeSantis said. "While we can not determine the exact cause of their demise, it is unlikely that the extinction of these cats was a result of gradually declining prey."

Currently, the scientists are examining other carnivores at the La Brea tar pits, "including the extinct giant short-faced bear and the extant mountain lion that is found both during the Pleistocene at La Brea and in southern California and elsewhere today," DeSantis told LiveScience. "Essentially, we are trying to clarify the biology and diets of these carnivores during the past to further evaluate why the short-faced bear went extinct and, potentially, why the mountain lion did not."

DeSantis and Ungar, with their colleagues Blaine Schubert and Jessica Scott, detailed their findings online Dec. 26 in the journal PLOS ONE.

Follow LiveScience on Twitter @livescience. We're also on Facebook?& Google+.

Copyright 2012 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/starvation-didnt-wipe-sabertooth-cats-155503846.html

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Ryan wants to be Jets coach for 'next 15 years'

By DENNIS WASZAK Jr.

AP Sports Writer

Associated Press Sports

updated 3:42 p.m. ET Dec. 28, 2012

FLORHAM PARK, N.J. (AP) - Rex Ryan has no plans to go anywhere.

Doesn't want to, he said.

The feisty New York Jets coach opened his news conference Friday by denouncing a published report that said he would welcome being fired if owner Woody Johnson doesn't make significant personnel and coaching changes to the offense.

"There was a report that was untrue," Ryan said. "The fact is, and it's simple: This is the only team that I want to coach. Period. This is my team. These are my players. I don't want to coach somebody else's players. This is the team I want to coach."

With the Jets (6-9) out of the playoffs for the second straight season, Ryan's job status has become somewhat tenuous in his fourth year. But Ryan said he was "mad as a hornet" when he read the Daily News story, and immediately called Johnson to deny it.

The paper, which quoted unidentified sources, said it stood by the report. The back page carried a picture of Ryan and a headline that said: "Rex Wants Out ... Unless Woody spends on Jets' woeful offense."

"It's a very solid report," said Teri Thompson, managing editor for sports at the Daily News.

Ryan said he was contacted by the reporter Thursday night, but his response wasn't included. Thompson said it was an off-the-record comment and as such was not published.

"There's no bigger Jet than me," Ryan insisted. "I want to be the Jets' head coach for the next 15 years."

Several Jets players said Ryan talked about the story with them in the team meeting earlier in the day, but declined to elaborate on what was said.

The Jets are preparing to finish their season at Buffalo on Sunday. In limbo are the futures of Ryan, general manager Mike Tannenbaum, offensive coordinator Tony Sparano and quarterbacks Tim Tebow and Mark Sanchez.

"Let's face it, I wear Jets stuff every single day," Ryan said. "I'm proud to be a Jet. Sometimes I'm proud to be a Jet more than others. I mean, this season has been a rough one. But this is my team that's how I approach it. I believe that we can accomplish what I set out to do when I took the job. And that's the truth."

---

Online: http://pro32.ap.org/poll and http://twitter.com/AP-NFL

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Prime-time win for?Redskins

PFT Picks: For the second straight year, the NFC East title game returns to prime time in Week 17. For the second straight year, the Cowboys come up short.

Kacsmar: A lot on the line in finale

Week 17 offers numerous playoff scenarios, the last two playoff berths, and one more attempt to rewrite the NFL record book. Here is your handy guide to what to watch for this Sunday.

Source: http://nbcsports.msnbc.com/id/46077643/ns/sports-nfl/

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Woman set on fire in L.A. as she sleeps on bench

LOS ANGELES (AP) ? For more than 10 years, the homeless woman slept on the same plastic bus stop bench at a busy intersection in the San Fernando Valley, no matter how cold it was or if it was raining.

The 67-year-old, described by one church volunteer who saw her regularly as the "sweetest lady on the street," was nestled in her regular spot early Thursday when the unthinkable happened: A man came out of a nearby drug store, doused her with a flammable liquid and set her ablaze.

She was taken to a hospital, where she was listed in critical condition.

Witness Erickson Ipina called 911, and police arrested Dennis Petillo, 24, a short time later. He was booked for investigation of attempted murder and was held on $500,000 bail. It wasn't immediately known if he had retained an attorney.

"He just poured it all over the old lady," Ipina told reporters at the scene. "Then he threw the match on her and started running."

Police provided no possible motive and released no details on Petillo. The victim's name also was withheld.

LAPD Deputy Chief Kirk Albanese told the Los Angeles Times it was unclear whether Petillo spoke to the woman before he allegedly set her ablaze.

"There was no incident or dispute or clear motivation for this horrific attack. He did not know his victim. It defies explanation," Albanese said. "He is not of sound mind. ... The motive is mental illness."

The attack shocked nearby residents, and later Thursday about a dozen people held vigil around the charred bench, urging motorists to honk their horns in support of homeless rights. One sign placed on the bench read, "Our Prayers to Violet," believed to be the victim's first name.

Tej Deol, 31, who resides at a nearby sober living house, said the woman made the bench her home and often could be found sleeping there after sundown. He said he saw her Christmas Eve, getting ready to eat some soup.

"I told her, 'Merry Christmas and happy New Year,' and she said she was doing good," Deol said. "She was so kind. She was happy to have someone talk to her."

Thursday's incident was at least the third in Los Angeles County since October where people were set on fire.

Last week, a 55-year-old man was seriously injured when he was torched as he slept outside a doughnut shop in Norwalk. Two months earlier, Long Beach police said Jacob Timothy Lagarde, 27, threw a lit Molotov cocktail at a man who had been waiting for his father outside a store. Lagarde has since been charged with attempted murder and five other counts.

Los Angeles police are investigating whether Petillo might be tied to any other similar crimes, but at this point detectives don't believe he is, Cmdr. Andrew Smith said.

As the number of flowers and candles around the scorched bench grew Thursday, people who knew the victim tried to comprehend why a woman who seemed so benign could be so viciously attacked.

Robert Wyneken, 75, who volunteers at a nearby church that serves meals for the less than fortunate, called Violet the "sweetest lady on the street." He said she was quiet, independent and resourceful.

Wyneken said she supported herself by recycling cans and didn't like to panhandle. He said there were efforts to get her housing and in contact with family, but she wouldn't have it.

"I just think she had something in her life where she wanted to be alone," he said. "She didn't want to be a burden to anybody."

Wyneken, Deol and others said they were deeply troubled by what had happened at the bus stop.

"The guy who did this should spend the rest of his life in jail," Deol said.

Steve Williams, 62, who identified himself as a homeless veteran, said he is aware of the dangers of sleeping on the street but that it's difficult to find space at nearby shelters, especially at this time of year.

"We are all human. No one should be treated like that," he said.

Source: http://news.yahoo.com/woman-set-fire-la-she-sleeps-bench-173532304.html

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